Microjet Technology
The Microjet Laboratory Processor offers advantages over conventional high pressure homogenisers and mills and offers particle size reduction and process control capability second to none. Microjet Systems are engineered specifically for pharmaceuticals, biotech and healthcare applications. They are suitable for fine dispersions, emulsions and for cell disruption. Operating at up to 25,000 psi, in the laboratory, each Microjet processor is fitted with our unique diamond interaction chamber. Diamond provides superior wear characteristics, superior chemical resistance and unique heat transmission properties. The Microjet produces extremely high liquid velocities which give very high levels of shear resulting in very fine, tight particle size distributions and very small particles of exceptional consistency. The process is fully scaleable and can be made fully cGMP compliant for asceptic and sterile applications. Laboratory and pilot scale machines can be bespoke designed to fit isolators and laminar flow cabinets. Low pressure machines are available operating to 2,000 psi and to 5,000 psi.
How Does It Work?
Microjet Technology uses the principle of liquids moving at very high velocity in Microfluidic channels.
The same principle is used in conventional homogeniser but at a much lower velocity and therefore energy.
What Kind of Products Are Best Suited To This technology?
Where there is a need for small particle size, typically sub-micron combined with a uniform distribution, and contamination free. This is particularly relevant to pharmaceuticals, biotechnology [particularly cell disruption] and healthcare. Or where other methods have failed.
What Kind of Products Are Not Suited To This technology?
It is not suitable for bulk or commodity goods. For example commodity pigments or paint production would not be cost effective, and traditional bead mills would be more appropriate. Food ingredients are usually best produced using standard homogenisers.
How Does It Compare With Traditional Homogenisers?
It often produces a smaller particle size and is more efficient.
What governs the final particle size?
The final particle size of an emulsion or dispersion is dependent on the energy applied and on the chemistry. The surfactants and electrical charge play a key role. The smaller the particle size, the larger the particles' surface area and the greater the role of electrical charge on the stability.
Is Smaller Particle Size Better?
Very often. If the mean size is smaller then drugs are more easily absorbed in or on the body. Formulations are generally more stable.
Does Higher Pressure Produce Smaller Particle Sizes?
Not necessarily.